PROGRAM  

8h30 : WELCOME

9h00-9h10 : INTRODUCTION

9h10-10h10 : Session 1 – Cancer Development in Older People

Chairs: Bruno Cardinaud and Hamid Rezvani

·Pierre Soubeyran: Identification of ageing biomarkers for better tailoring of cancer treatment in older patients with lung cancer. Project CLASSE (7+3’)

·Catherine Sawai: Lineage tracing and ageing (10+5’)

·Sarah Duchamp: Genetic regulation of hematopoiesis during ageing (7+3’)

·Edith Chevret: Sézary cell, a neoplastic T-Cell of an older patient syndrome (7+3’)​​​​​

·Lucie Brisson or Thomas Mathivet : Biomarkers and therapeutic targets of brain tumours (7+3’)

10h10-11h10 : Session 2 – Neuroepidemiology of Ageing

Chairs: Catherine Helmer and Claire Roubaud

·Thierry Couffinhal: Research aspects of the IHU "Precision and global vascular brain health institute (VBHI)" (10+5’)

·Idris Dulau: Characterization of the retinal vascular network using a deep learning approach for the assessement of cerebro and cardiovascular health (7+3’)

·Ilana Caro: Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease (7+3’)

·Cécilia Samieri: The B cube cohort: a new epidemiological research platform to study the brain aging exposome (10+5’)

·Catherine Helmer: Viral infections and neurodegenerative diseases (7+3’)

30min : COFFEE BREAK

11h40-12h40 : Session 3 – Innovative Approaches for the Screening, Support and Management of Ageing

Chairs: Karine Pérès and Hélène Amieva

·Hélène Sauzeon : Digital technology to support healthy aging : Research examples on smart home and computerized cognitive training (10+5’)

·Pernelle Noize : Use and misuse of medications in elderly population (10+5’)

·Hélène Amieva : Experimental models of care and management in Alzheimer's disease: towards alternative models of nursing homes ? (10+5’)

·Bénédicte Merle : MacuTest a digital tool for prediction and prevention of age-related macular degeneration (7+3’)

12h40-13h10 Keynote lecture - Neurobiology

Jean-Christophe Delpech : Pathological and physiological aging and cognition : cellular and vesicular mechanisms (20+10’)

80min : LUNCH

14h40-15h40 : Session 4 – Immune Ageing and Vulnerability

Chairs: Julie Dechanet-Merville and Victor Appay

·Andrea Boizard-Moracchini: Immunomonitoring of older cancer patients (PREPARE) (10+5’)

·Isabelle Pellegrin : Immunomonitoring of older cancer patients (the PREPARE study) (10+5’)

·Victor Appay : COVID-19 severity and SARS-CoV-2 specific T cell responses (10+5’)

·Florent Guerville : Inflammageing and liver transplantation (7+3’)

·Claire Roubaud : Atybactage project (Atypical bacterial infections in older people) (7+3’)

·Noémie Gensous : Lupage project (Lupus and Immunosenescence) (7+3’)

15h40-16h40 : Session 5 – Ageing and Cardiovascular Disorders

Chairs: Thierry Couffinhal and Alain-Pierre Gadeau

·Marie Ange Renault: Cardiac pericytes are necessary to prevent cardiac inflammation and systolic dysfunction during ageing (10+5’)

·Mélody Dufossé: Acquired chromosomal abnormalities in hematopoietic cells during ageing: the example of Y chromosome mosaic losses (7+3’)

·Olivier Mansier: Role of clonal hematopoiesis of undetermined potential and Y chromosome losses in cardiovascular pathologies (10+5’)

·Ninon Foussard: ICAM1 overexpression impairs microvessel perfusion and ischemic limb recovery in the setting of diabetes (7+3’)

30min : COFFEE BREAK

17h10-17h30 : Conclusion => La vue du philosophe : Maël Lemoine​​​​​​​

End of the day