Ce séminaire est organisé à l’initiative de Anne Royou.
Titre de l’intervention :
Cytokinesis and the Evolution of Metazoa
Résumé : Obligate multicellularity has evolved multiple times, including at the origin of Metazoa. The molecular events leading to the acquisition of multicellularity in animals have not been previously delineated. In principle, multicellularity can arise via cell-cell adhesion or incomplete cytokinesis, or a combination thereof. The vast majority of metazoan germlines contain intercellular bridges resulting from incomplete cytokinesis, suggesting this feature is ancestral. I will discuss the structural conservation of centralspindlin/Ect2, delve into their evolutionary history, and highlight the numerous roles that they perform in cytokinesis including cytokinetic bridge stabilization. Collectively, these findings indicate that centralspindlin/Ect2 were refined in the last common ancestor of metazoa and they remain under strong selection. These results indicate that the evolutionary refinement of centralspindlin/Ect2 contributed the emergence of animals by promoting both multicellularity and germline development.
🔗 Plus d'informations sur le conférencier :
Michael Glotzer – University of Chicago
