Séminaire de Bioinformatique et Biologie Computationnelle

Orateur : Vincent Pedergnana, MiVEGEC (Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle), CNRS - IRD - Université de Montpellier

Titre : Human and viral genomics of infections

Abstract :

My research program focuses on the identification of human and viral genetic factors that can explain the observed variability in the natural history of infectious diseases, particularly those caused by viruses. I use approaches of statistical genetics, such as genome-wide association studies or candidate gene association study, as well as more original approaches, using family information to estimate the familial correlation of a trait or combining linkage analysis and association analysis within families. In addition, I contributed to the development of a novel method to explore the interactions between the whole human genome and the whole virus genome by jointly analysing genotyping and sequencing data in a regression framework. In this talk I will present details of the bioinformatics pipeline do generate the data from the host and the virus and the results from my research on hepatitis C virus and dengue virus.