"Deciphering the principles of epithelial organization that maintain tissue integrity and homeostasis"
Delphine Delacour est DR1 au CNRS et responsable de l'équipe "Epithelial Monolayer Morphogenesis” à l'IBDM, Marseille.
Avant de s'installer à Marseille, elle developpait sa thématique dans l'équipe co-dirigée par B. Ladoux et R.M. Mège, à l'Institut Jacques Monod, Paris.
Récipiendaire de nombreux financements, son équipe a obtenu le soutien d'un Programme Labellisé (PGA équipe) de la Fondation ARC pour la recherche sur le Cancer en 2023.
Elle vient de publier un superbe article intitulé "Length-limitation of astral microtubules orients cell divisions in intestinal crypts" dans Dev. Cell (doi.org/10.1101/2022.09.02.506333) , mais aussi bien d'autres publications dans des journaux de renom.
Abstract:
Epithelia act as a physical barrier against external aggressions but also ensure organ functionality. If not correctly assembled or dysfunctional, this leads to pathological situations that include a variety of diseases spanning from rare developmental syndromes or cancer. How epithelia coordinate and harmonize the responses of each cell with not only their nearest neighbors, but entire tissue, to guarantee proper spatial arrangement, integrity and functionality is still not well understood. So far, the question of epithelial coherence has been mainly tackled in invertebrate models during development or in transformed cell lines in culture.
The intestinal epithelium is a tremendous model for this field of research, as it is one of the most fast-proliferative and regenerative in mammalian organisms. In addition, the intestinal tissue is subject to adverse situations, where the balance between cell proliferation, differentiation and death has to be strictly maintained. However, the study of the cellular and developmental mechanisms that govern the development and architecture of the intestinal tissue is still in its infancy.
The general objective of our project focuses on understanding the determination and maintenance of intestinal functional domains, and to evaluate their spatiotemporal coordination. More specifically, our aims are: 1) to define mechanisms controlling the integrity of the proliferative domain, and assess their impact on the crypt development; 2) to characterize the epithelial connectivity and collective behavior of the differentiated domain in homeostatic conditions or under challenging contexts.
One of the strong aspects of our research is to confront in vivo and in vitro murine and human disease models, and to combine different approaches from advanced cell biology, tissue engineering, histology, molecular biology, biophysics and computational modelling. This strategy allows us to determine the adaptive processes that epithelial cells employ to polarize and organize in a given environment, and enhance their ability to modulate their fate.

Séminaire de Delphine Delacour : "Deciphering the principles of epithelial organization that maintain tissue integrity and homeostasis"
Delphine Delacour, Institut de Biologie du Développement de Marseille est invité par Isabelle Sagot (IBGC) pour un séminaire le 5 mars à 11h en salle de conférence de l'IBGC.
Salle de conférence de l'IBGC, Campus Carreire,