"The Oxidative Phosphorylation System revisited"
José Antonio Enríquez is Group Leader at CNIC (Centro nacional de investigaciones cardiovasculares, Madrid, Spain). His work focuses on functional consequences of the genetic variability of mtDNA and developing of new models of the structural organization of the ETC. Research from his laboratory has tremendously contributed our understanding of the processes by which cells optimize and molecularly regulate their metabolic capacity, inducing structural changes in the mitochondrial electron transport chain. He will be presenting his latest work on mother-to-offspring transmission of mitochondrial DNA, and on the assembly of ETC assembly. He is involved in many international networks and is a HFSP researcher. His lectures are of high quality and very comprehensive.
Key publications:
Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy.
Latorre-Pellicer A, Lechuga-Vieco AV, Johnston IG, Hämäläinen RH, Pellico J, Justo-Méndez R, Fernández-Toro JM, Clavería C, Guaras A, Sierra R, Llop J, Torres M, Criado LM, Suomalainen A, Jones NS, Ruíz-Cabello J, Enríquez JA.
Cell Metab. 2019 Dec 3;30(6):1120-1130.e5. doi: 10.1016/j.cmet.2019.09.007. Epub 2019 Oct 3. PMID:31588014
Ablation of the stress protease OMA1 protects against heart failure in mice.
Acin-Perez R, Lechuga-Vieco AV, Del Mar Muñoz M, Nieto-Arellano R, Torroja C, Sánchez-Cabo F, Jiménez C, González-Guerra A, Carrascoso I, Benincá C, Quiros PM, López-Otín C, Castellano JM, Ruíz-Cabello J, Jiménez-Borreguero LJ, Enríquez JA.
Sci Transl Med. 2018 Mar 28;10(434). pii: eaan4935. doi: 10.1126/scitranslmed.aan4935. PMID: 29593106
Mechanism of super-assembly of respiratory complexes III and IV.
Cogliati S, Calvo E, Loureiro M, Guaras AM, Nieto-Arellano R, Garcia-Poyatos C, Ezkurdia I, Mercader N, Vázquez J, Enriquez JA.
Nature. 2016 Nov 24;539(7630):579-582. doi: 10.1038/nature20157. Epub 2016 Oct 24. PMID: 27775717
Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.
Latorre-Pellicer A, Moreno-Loshuertos R, Lechuga-Vieco AV, Sánchez-Cabo F, Torroja C, Acín-Pérez R, Calvo E, Aix E, González-Guerra A, Logan A, Bernad-Miana ML, Romanos E, Cruz R, Cogliati S, Sobrino B, Carracedo Á, Pérez-Martos A, Fernández-Silva P, Ruíz-Cabello J, Murphy MP, Flores I, Vázquez J, Enríquez JA.
Nature. 2016 Jul 28;535(7613):561-5. Epub 2016 Jul 6. PMID: 27383793
Supercomplex assembly determines electron flux in the mitochondrial electron transport chain.
Lapuente-Brun E, Moreno-Loshuertos R, Acín-Pérez R, Latorre-Pellicer A, Colás C, Balsa E, Perales-Clemente E, Quirós PM, Calvo E, Rodríguez-Hernández MA, Navas P, Cruz R, Carracedo Á, López-Otín C, Pérez-Martos A, Fernández-Silva P, Fernández-Vizarra E, Enríquez JA.
Science. 2013 Jun 28;340(6140):1567-70. doi: 10.1126/science.1230381. PMID: 23812712